Resistant starch reduces colonic and urinary p-cresol in rats fed a tyrosine-supplemented diet, whereas konjac mannan does not

Biosci Biotechnol Biochem. 2016 Oct;80(10):1995-2000. doi: 10.1080/09168451.2016.1194183. Epub 2016 Jun 13.


The effect of resistant starch (RS) and konjac mannan (KM) to maintain and improve the large intestinal environment was compared. Wistar SPF rats were fed the following diets for 4 weeks: negative control diet (C diet), tyrosine-supplemented positive control diet (T diet), and luminacoid supplemented diets containing either high-molecular konjac mannan A (KMAT diet), low-molecular konjac mannan B (KMBT diet), high-amylose cornstarch (HAST diet), or heat-moisture-treated starch (HMTST diet). The luminacoid-fed group had an increased content of short-chain fatty acids in the cecum. HAS caused a significant decrease in p-cresol content in the cecum, whereas KM did not. Urinary p-cresol was reduced in the HAST group compared with the T group, but not the KM fed groups. Deterioration in the large intestinal environment was only improved completely in the HAST and HMTST groups, suggesting that RS is considerably more effective than KM in maintaining the large intestinal environment.

Keywords: konjac mannan; p-cresol; phenol; resistant starch; short-chain fatty acid.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cecum / drug effects*
  • Cecum / growth & development
  • Cecum / metabolism*
  • Cresols / metabolism
  • Cresols / urine*
  • Dietary Supplements*
  • Fatty Acids / metabolism
  • Male
  • Mannans / pharmacology
  • Organ Size / drug effects
  • Phenol / metabolism
  • Rats
  • Rats, Wistar
  • Starch / metabolism
  • Starch / pharmacology*
  • Tyrosine / pharmacology*


  • Cresols
  • Fatty Acids
  • Mannans
  • 4-cresol
  • Phenol
  • (1-6)-alpha-glucomannan
  • Tyrosine
  • Starch