Neurovascular complications following carotid body paraganglioma resection

Eur Ann Otorhinolaryngol Head Neck Dis. 2016 Nov;133(5):319-324. doi: 10.1016/j.anorl.2016.05.006. Epub 2016 Jun 11.


Objective: The present consecutive case series reports our experience in the management of carotid body paraganglioma and aims to assess whether the Shamblin classification or tumor size are predictive of early and late postoperative neurovascular complications.

Material and methods: A retrospective study included 54 carotid body tumor resections in 49 patients, between 1980 and 2011. Data comprised early (<1month) and late (18 months) postoperative neurovascular complications.

Results: Early postoperative complications occurred in 31 cases, including 30 cases of cranial nerve deficit (56%). Cranial nerve deficit occurred in 83% of Shamblin III carotid body paragangliomas and was associated with significantly larger mean tumor size (4±1.4cm versus 2.9±1.3cm; P<0.01). Shamblin III tumor and tumor size>3.2cm emerged as predictive factors for early postoperative peripheral neurological complications. Eight patients (17%) showed no cranial nerve deficit recovery, even after 18 months' follow-up; no predictive factors could be identified for this.

Conclusion: Surgical resection remains the only curative treatment in carotid body paraganglioma, with low vascular morbidity. However, early postoperative nerve deficit remains frequent (56%), although mostly temporary, with 17% definitive sequelae at 18 months. Tumor size and Shamblin classification are predictive of early neurovascular complications.

Keywords: Carotid body paraganglioma; Neurovascular complications; Shamblin classification; Surgery.

MeSH terms

  • Adult
  • Carotid Body Tumor / pathology
  • Carotid Body Tumor / surgery*
  • Cranial Nerve Diseases / etiology*
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neoplasm, Residual
  • Postoperative Complications*
  • Retrospective Studies