Synthesis, antimalarial properties and 2D-QSAR studies of novel triazole-quinine conjugates

Bioorg Med Chem. 2016 Aug 15;24(16):3527-39. doi: 10.1016/j.bmc.2016.05.060. Epub 2016 May 30.


Click chemistry technique led to novel 1,2,3-triazole-quinine conjugates 8a-g, 10a-o, 11a-h and 13 utilizing benzotriazole-mediated synthetic approach with excellent yields. Some of the synthesized analogs (11a, 11d-h) exhibited antimalarial properties against Plasmodium falciparum strain 3D7 with potency higher than that of quinine (standard reference used) through in vitro standard procedure bio-assay. Statistically significant BMLR-QSAR model describes the bio-properties, validates the observed biological observations and identifies the most important parameters governing bio-activity.

Keywords: Antimalarial; Click chemistry; QSAR; Quinine; Triazole.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / chemical synthesis*
  • Antimalarials / chemistry
  • Antimalarials / pharmacology*
  • Biological Assay
  • Carbon-13 Magnetic Resonance Spectroscopy
  • Drug Design
  • Inhibitory Concentration 50
  • Plasmodium falciparum / drug effects
  • Proton Magnetic Resonance Spectroscopy
  • Quantitative Structure-Activity Relationship
  • Quinine / chemistry*
  • Spectrometry, Mass, Electrospray Ionization
  • Triazoles / chemistry*


  • Antimalarials
  • Triazoles
  • Quinine