Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. May-Jun 2016;48(3):292-7.
doi: 10.4103/0253-7613.182884.

Weekly Injection of Histaglobulin Produces Long-Term Remission in Chronic Urticaria: A Prospective Clinical Study

Free PMC article

Weekly Injection of Histaglobulin Produces Long-Term Remission in Chronic Urticaria: A Prospective Clinical Study

Gurumoorthy Rajesh et al. Indian J Pharmacol. .
Free PMC article


Objective: Treatment of chronic urticaria (CU) can be difficult in many patients. Achieving long-term remission and reducing the requirement of antihistamines are vital in CU. The objective of this study was to assess the effectiveness of injection histaglobulin, a complex of histamine and human immunoglobulin, in producing relief in patients with CU.

Materials and methods: Fifty-one patients with CU were enrolled into this prospective clinical study. Patients were administered 1 ml of injection histaglobulin subcutaneous for 8 consecutive weeks. They were also prescribed tablet levocetirizine 5 mg to be taken when required (but not more than the permitted dosage). Efficacy was assessed using urticaria activity score (UAS) which has a maximum score of 33/day, during each weekly visit. Final assessment was done after 24 weeks.

Results: Twenty-nine patients had completed the entire 8-week drug regimen. Mean basal UAS was 18.9 ± 6.3 and it reduced to 80.4% by 8 weeks. The angioedema sub-score reduced by 89.8%. Anti-histamine pill burden also reduced significantly. By 24 weeks of starting the therapy, 23 patients (45%) had attained complete remission. No adverse effects to the drug were observed.

Conclusions: Histaglobulin was found to be effective in producing long-term remission and it reduced the antihistamine requirement as well. Thus, it can serve as an effective alternative to existing treatment modalities.

Keywords: Angioedema; anti-histamines; chronic urticaria; histaglobulin; urticaria activity score.


Figure 1
Figure 1
Flow of study participants
Figure 2
Figure 2
Serial means of urticaria activity score recorded during each week

Similar articles

See all similar articles


    1. Goh CL, Tan KT. Chronic autoimmune urticaria: Where we stand? Indian J Dermatol. 2009;54:269–74. - PMC - PubMed
    1. Yadav S, Upadhyay A, Bajaj AK. Chronic urticaria: An overview. Indian J Dermatol. 2006;51:171–7.
    1. Powell RJ, Leech SC, Till S, Huber PA, Nasser SM, Clark AT. BSACI guideline for the management of chronic urticaria and angioedema. Clin Exp Allergy. 2015;45:547–65. - PubMed
    1. Tseng JT, Lee WR, Lin SS, Hsu CH, Yang HH, Wang KH, et al. Autologous serum skin test and autologous whole blood injections to patients with chronic urticaria: A retrospective analysis. Dermatolog Sin. 2009;27:27–36.
    1. Konstantinou GN, Asero R, Maurer M, Sabroe RA, Schmid-Grendelmeier P, Grattan CE. EAACI/GA (2) LEN task force consensus report: The autologous serum skin test in urticaria. Allergy. 2009;64:1256–68. - PubMed