Abstract
Background:
Interferon α‑2b (IFN α‑2b) is an established and well-tolerated treatment for ocular surface squamous neoplasia (OSSN).
Method:
Report of complications in two patients with OSSN and rheumatoid arthritis treated with adjuvant topical IFN α‑2b.
Results:
One patient developed a scleral melt and the other one severe keratitis. After discontinuing treatment with IFN α‑2b both patients showed considerable improvement.
Conclusion:
Immunosuppressed patients with OSSN under topical IFN α‑2b should be closely monitored for early detection of complications.
Keywords:
Complications; IFN α‑2b; Immune suppression; Ocular surface squamous neoplasia; Rheumatoid arthritis.
MeSH terms
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Aged
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Arthritis, Rheumatoid / complications*
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Carcinoma, Squamous Cell / complications
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Carcinoma, Squamous Cell / drug therapy*
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Conjunctival Neoplasms / complications
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Conjunctival Neoplasms / drug therapy*
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Female
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Humans
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Interferon alpha-2
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Interferon-alpha / adverse effects*
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Interferon-alpha / therapeutic use*
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Keratitis / chemically induced*
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Keratitis / pathology
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Keratitis / prevention & control
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Middle Aged
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Recombinant Proteins / adverse effects
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Recombinant Proteins / therapeutic use
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Scleral Buckling
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Scleral Diseases / chemically induced*
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Scleral Diseases / pathology
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Scleral Diseases / prevention & control
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Treatment Outcome
Substances
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Interferon alpha-2
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Interferon-alpha
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Recombinant Proteins