Prebiotic and Synbiotic Treatment before Colorectal Surgery--Randomised Double Blind Trial

Coll Antropol. 2016 Apr;40(1):35-40.


The aim of our study was to demonstrate higher concentrations of lactic acid bacteria (LAB) on the colonic mucosa in operated colorectal cancer patients treated with oral intake of synbiotics or prebiotics preoperatively. We also tried to prove that the systemic inflammatory response after surgery is not so severe in patients who took synbiotics or prebiotics, furthermore these patients have less postoperative complications and a favorable postoperative course. 73 patients with preceding colorectal operations were recruited. They were randomized into three groups. One group received preoperatively prebiotics, the second synbiotics in and third was preoperatively cleansed. We have defined the number of four different probiotic bacteria on colonic mucosa with polymerase chain reaction (PCR). Serum levels of interleukin-6, CRP, fibrinogen, white cell count and differential blood count were measured pre- and postoperatively to determine systemic inflammatory response. We succeed in confirming that in the synbiotic group there were considerably more LAB presented on the mucosa. They did pass the upper gastrointestinal tract and were isolated in colonic mucosa. On the other hand, we did not find any statistical differences in systemic inflammatory response measured by upper factors and no differences in postoperative course and complications rate between all three groups.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • C-Reactive Protein / immunology
  • Colectomy*
  • Colorectal Neoplasms / surgery*
  • DNA, Bacterial / analysis*
  • Double-Blind Method
  • Female
  • Fibrinogen / immunology
  • Humans
  • Interleukin-6 / immunology
  • Lactobacillus / genetics
  • Lactobacillus plantarum / genetics
  • Leuconostoc / genetics
  • Leukocyte Count
  • Male
  • Middle Aged
  • Pediococcus / genetics
  • Postoperative Complications / immunology
  • Postoperative Complications / prevention & control*
  • Prebiotics*
  • Preoperative Care / methods*
  • Probiotics
  • Synbiotics*
  • Systemic Inflammatory Response Syndrome / immunology
  • Systemic Inflammatory Response Syndrome / prevention & control*


  • DNA, Bacterial
  • IL6 protein, human
  • Interleukin-6
  • Prebiotics
  • Fibrinogen
  • C-Reactive Protein