Addictive drugs, arrhythmias, and cardiac inward rectifiers

Europace. 2017 Mar 1;19(3):346-355. doi: 10.1093/europace/euw071.

Abstract

In many addictive drugs including alcohol and nicotine, proarrhythmic effects were reported. This review provides an overview of the current knowledge in this field (with a focus on the inward rectifier potassium currents) to promote the lacking data and appeal for their completion, thus, to improve understanding of the proarrhythmic potential of addictive drugs.

Keywords: Addictive drug; Arrhythmias; Ethanol; Inward rectifier; Nicotine.

Publication types

  • Review

MeSH terms

  • Action Potentials
  • Alcohol Drinking / adverse effects*
  • Animals
  • Arrhythmias, Cardiac / chemically induced*
  • Arrhythmias, Cardiac / metabolism
  • Arrhythmias, Cardiac / physiopathology
  • Ethanol / adverse effects*
  • Heart Conduction System / drug effects*
  • Heart Conduction System / metabolism
  • Heart Conduction System / physiopathology
  • Heart Rate / drug effects*
  • Humans
  • Nicotine / adverse effects*
  • Nicotinic Agonists / adverse effects*
  • Potassium / metabolism*
  • Potassium Channels, Inwardly Rectifying / drug effects*
  • Potassium Channels, Inwardly Rectifying / metabolism
  • Risk Factors
  • Smoking / adverse effects*

Substances

  • Nicotinic Agonists
  • Potassium Channels, Inwardly Rectifying
  • Ethanol
  • Nicotine
  • Potassium