Prophylaxis of Hereditary Angioedema Attacks: A Randomized Trial of Oral Plasma Kallikrein Inhibition With Avoralstat

J Allergy Clin Immunol. 2016 Sep;138(3):934-936.e5. doi: 10.1016/j.jaci.2016.03.043. Epub 2016 May 11.

Publication types

  • Letter
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Angioedemas, Hereditary / drug therapy*
  • Angioedemas, Hereditary / metabolism
  • Complement C1 Inhibitor Protein / metabolism
  • Cross-Over Studies
  • Enzyme Inhibitors / therapeutic use*
  • Female
  • Humans
  • Male
  • Plasma Kallikrein / antagonists & inhibitors*
  • Proline / analogs & derivatives*
  • Proline / therapeutic use

Substances

  • Complement C1 Inhibitor Protein
  • Enzyme Inhibitors
  • Proline
  • Plasma Kallikrein
  • avorelin