Opsoclonus in organophosphate poisoning

Arch Neurol. 1989 Jun;46(6):704-5. doi: 10.1001/archneur.1989.00520420126037.


Transient opsoclonus was observed in a patient who attempted suicide with the organophosphate insecticide Malathion (diethyl[dimethoxyphosphinothioyl]thiobutanedioate). Several toxins can cause opsoclonus, and these must be considered in its differential diagnosis. Eye movement disorders are one of the more common manifestations of organophosphate intoxication, and opsoclonus should now be included among these. Acetylcholine may be a neurotransmitter in the ocular motor pathway.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Extremities
  • Humans
  • Malathion / poisoning
  • Male
  • Movement Disorders / chemically induced
  • Muscular Diseases / chemically induced
  • Oculomotor Muscles*
  • Organophosphate Poisoning*
  • Reflex / drug effects
  • Suicide, Attempted


  • Malathion