Why NAD(+) Declines during Aging: It's Destroyed

Michael B Schultz; David A Sinclair

doi:10.1016/j.cmet.2016.05.022

Why NAD(+) Declines during Aging: It's Destroyed

Cell Metab. 2016 Jun 14;23(6):965-966. doi: 10.1016/j.cmet.2016.05.022.

Authors

Michael B Schultz¹, David A Sinclair²

Affiliations

¹ Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
² Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Pharmacology, University of New South Wales, Sydney 2052, Australia. Electronic address: david_sinclair@hms.harvard.edu.

Abstract

NAD(+) is required not only for life but for a long life. In this issue, Camacho-Pereira et al. (2016) implicate CD38 in the decline of NAD(+) during aging, with implications for combating age-related diseases.

MeSH terms

ADP-ribosyl Cyclase 1 / metabolism
Aging / metabolism*
Animals
Mice
Mitochondria / metabolism
Models, Biological
NAD / metabolism*

Substances

NAD
ADP-ribosyl Cyclase 1

Abstract

MeSH terms

Substances

Grants and funding