A Ribosomal Perspective on Proteostasis and Aging

Kristan K Steffen; Andrew Dillin

doi:10.1016/j.cmet.2016.05.013

A Ribosomal Perspective on Proteostasis and Aging

Cell Metab. 2016 Jun 14;23(6):1004-1012. doi: 10.1016/j.cmet.2016.05.013.

Authors

Kristan K Steffen¹, Andrew Dillin²

Affiliations

¹ Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
² Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: dillin@berkeley.edu.

PMID: 27304502
DOI: 10.1016/j.cmet.2016.05.013

Abstract

As the first and most direct process influencing the proteostasis capacity of a cell, regulation of translation influences lifespan across taxa. Here we highlight some of the newly discovered means by which translational regulation affects cellular proteostasis, with a focus on mechanisms that may ultimately impinge upon the aging process.

Publication types

Review

MeSH terms

Aging / metabolism*
Animals
Humans
Models, Biological
Protein Biosynthesis
Proteins / metabolism*
Ribosomes / metabolism*
Stress, Physiological

Substances

Proteins