Sliding Hydrogels with Mobile Molecular Ligands and Crosslinks as 3D Stem Cell Niche

Adv Mater. 2016 Sep;28(33):7257-63. doi: 10.1002/adma.201601484. Epub 2016 Jun 15.


The development of a sliding hydrogel with mobile crosslinks and biochemical ligands as a 3D stem cell niche is reported. The molecular mobility of this sliding hydrogel allows stem cells to reorganize the surrounding ligands and change their morphology in 3D. Without changing matrix stiffness, sliding hydrogels support efficient stem cell differentiation toward multiple lineages including adipogenesis, chondrogenesis, and osteogenesis.

Keywords: cell niches; cyclodextrins; sliding hydrogels.

MeSH terms

  • Adipogenesis
  • Chondrogenesis
  • Cross-Linking Reagents / chemistry*
  • Humans
  • Hydrogels / chemistry*
  • Ligands
  • Mesenchymal Stem Cells / cytology*
  • Osteogenesis
  • Stem Cell Niche*


  • Cross-Linking Reagents
  • Hydrogels
  • Ligands