Intrathecal baclofen infusion. Effect on bladder management programs in patients with myelopathy

Am J Phys Med Rehabil. 1989 Jun;68(3):112-5.

Abstract

Intrathecal administration of Baclofen, a GABA agonist, through an implantable drug delivery pump has been demonstrated to be effective in the treatment of limb spasticity in patients with myelopathy. Three patients, followed before and after pump placement, experienced satisfactory spasticity relief and improvement in areas of self-care and mobility. Improvement in the bladder management programs of each patient was noted. These changes coincided with improvement on urodynamic studies, defined as either an increase in bladder capacity or a decrease in sphincter dyssynergia. Changes in bladder function were associated with the initiation of intrathecal therapy and with changes in pump-delivered dosages. In selected patients, intrathecal baclofen infusion can have a beneficial effect on bladder management programs.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Baclofen / administration & dosage*
  • Female
  • Humans
  • Injections, Spinal
  • Male
  • Muscle Spasticity / drug therapy
  • Paraplegia / complications
  • Urinary Bladder / drug effects
  • Urinary Bladder / physiopathology
  • Urinary Bladder, Neurogenic / drug therapy*
  • Urinary Bladder, Neurogenic / etiology
  • Urinary Bladder, Neurogenic / physiopathology
  • Urodynamics / drug effects

Substances

  • Baclofen