Increased O-GlcNAcylation is emerging as a general characteristic of cancer cells that is critical for multiple oncogenic phenotypes. Recently, we demonstrated that elevated O-GlcNAcylation contributes to the metabolic shift seen in cancer through stabilization of the glycolytic regulator HIF-1α and links metabolism to stress and cancer cell survival.
Keywords: ER stress; GLUT1; HIF-1α; O-GlcNAcylation; OGT; cancer; epithelial; hexosamine biosynthetic pathway; metabolism.