Dysregulation of HIF2α and autophagy in renal cell carcinoma

Xian-De Liu; Haifeng Zhu; Adela DePavia; Eric Jonasch

doi:10.4161/23723548.2014.965643

Dysregulation of HIF2α and autophagy in renal cell carcinoma

Mol Cell Oncol. 2014 Oct 30;2(2):e965643. doi: 10.4161/23723548.2014.965643. eCollection 2015 Apr-Jun.

Authors

Xian-De Liu¹, Haifeng Zhu², Adela DePavia¹, Eric Jonasch¹

Affiliations

¹ Department of Genitourinary Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.
² Department of Melanoma; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.

Abstract

Our recent study shows that autophagy collaborates with proteasomes to degrade endothelial PAS domain-containing protein 1 (EPAS1, also known as HIF2α) in a manner dependent on Von Hippel-Lindau (VHL) and sequestosome 1 (SQSTM1/p62). The genetic dysregulation of autophagy is a common feature of different subtypes of renal cell carcinoma (RCC).

Keywords: HIF2α; VHL; autophagy; p53; p62; proteasome; renal cell carcinoma.