TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling

Mol Cell Oncol. 2015 Apr 18;2(3):e980134. doi: 10.4161/23723556.2014.980134. eCollection Jul-Sep 2015.

Abstract

In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).

Keywords: PTEN; Tribbles pseudokinases; animal models of cancer; prostate cancer; skin carcinogenesis.