The PREX1/Rac signaling axis: Potential as a biomarker and therapeutic target in breast cancer

Lloye M Dillon; Todd W Miller

doi:10.1080/23723556.2014.996016

The PREX1/Rac signaling axis: Potential as a biomarker and therapeutic target in breast cancer

Mol Cell Oncol. 2015 Apr 30;2(3):e996016. doi: 10.1080/23723556.2014.996016. eCollection 2015 Jul-Sep.

Authors

Lloye M Dillon¹, Todd W Miller²

Affiliations

¹ Department of Pharmacology and Toxicology; Norris Cotton Cancer Center; Geisel School of Medicine at Dartmouth; Dartmouth-Hitchcock Medical Center ; Lebanon, NH, USA.
² Department of Pharmacology and Toxicology; Norris Cotton Cancer Center; Geisel School of Medicine at Dartmouth; Dartmouth-Hitchcock Medical Center; Lebanon, NH, USA; Comprehensive Breast Program; Norris Cotton Cancer Center; Geisel School of Medicine at Dartmouth; Dartmouth-Hitchcock Medical Center; Lebanon, NH, USA.

Abstract

PREX1 is a Rac guanine exchange factor that coordinates signaling inputs from G protein-coupled receptors and receptor tyrosine kinases (RTKs). PREX1 creates a positive feedback loop to drive RTK, phosphatidylinositol 3-kinase (PI3K)/AKT, and MEK/ERK signaling. High PREX1 levels predict sensitivity to PI3K inhibitors in breast cancer cells.

Keywords: MEK; P-REX1; PI3K; breast cancer.