Information regarding the role of p73 in the regulation of angiogenesis has been incomplete and quite controversial. Remarkably, several groups, including ours, have recently demonstrated that TP73 plays a fundamental role in angiogenesis regulation and that differential expression of TP73 could have important consequences in tumor angiogenesis. Here, we discuss a possible model for p73 function in the regulation of developmental angiogenesis and tumor angiogenesis.
Keywords: TGF-β; angiogenesis; endothelial cell differentiation; endothelial cell migration; induced pluripotent stem cells; mouse embryonic stem cells; p73; vasculogenesis.