DNA damage tolerance branches out toward sister chromatid cohesion

Dana Branzei

doi:10.1080/23723556.2015.1035478

DNA damage tolerance branches out toward sister chromatid cohesion

Mol Cell Oncol. 2015 May 7;3(1):e1035478. doi: 10.1080/23723556.2015.1035478. eCollection 2016 Jan.

Author

Dana Branzei¹

Affiliation

¹ IFOM, FIRC Institute of Molecular Oncology , Milan, Italy.

Abstract

Genome duplication is temporarily coordinated with sister chromatid cohesion and DNA damage tolerance. Recently, we found that replication fork-coupled repriming is important for both optimal cohesion and error-free replication by recombination. The mechanism involved has implications for the etiology of replication-based genetic diseases and cancer.

Keywords: DNA damage tolerance; DNA replication; Developmental disorders; Polα/primase/Ctf4; mechanisms of oncogenesis and tumor progression; replication fork architecture; replication stress; repriming; sister chromatid cohesion.