ATM: An unexpected tumor-promoting factor in HER2-expressing tumors

Venturina Stagni; Veronica Oropallo; Daniela Barilà

doi:10.1080/23723556.2015.1054551

ATM: An unexpected tumor-promoting factor in HER2-expressing tumors

Mol Cell Oncol. 2015 Jun 10;3(2):e1054551. doi: 10.1080/23723556.2015.1054551. eCollection 2016 Mar.

Authors

Venturina Stagni¹, Veronica Oropallo², Daniela Barilà²

Affiliations

¹ Laboratory of Cell Signaling, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia , Rome, Italy.
² Laboratory of Cell Signaling, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, Italy; Department of Biology, University of Rome "Tor Vergata", Rome, Italy.

Abstract

ATM kinase is a gatekeeper of genome stability. However, its role in several other signaling pathways suggests that it might not always act as a tumor suppressor. Here, we discuss recent data that unveil a function of ATM as a tumor promoter in HER2-positive breast cancer.

Keywords: ATM kinase; HER2 receptor tyrosine kinase; HSP90; breast cancer; tumor suppressor genes and oncogenes.