Insulin-like growth factor I (IGF-I) stimulates regeneration of the rat sciatic nerve

Brain Res. 1989 May 8;486(2):396-8. doi: 10.1016/0006-8993(89)90531-3.


The effect of insulin-like growth factor I (IGF-I) was tested on regeneration of the rat sciatic nerve after a crush lesion. IGF-I was administered via miniosmotic pumps to the dorsal root ganglia or locally around the crush lesion. Regeneration of sensory fibers was measured after 3 or 4 days superfusion by pinching. IGF-I stimulated regeneration in both administration paradigms. Regeneration was inhibited if the nerve was perfused with specific antibodies to native IGF-I. The results suggest that endogenous extracellular IGF-I plays an important role during regeneration of peripheral nerve fibers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Immune Sera / pharmacology
  • Insulin-Like Growth Factor I / immunology
  • Insulin-Like Growth Factor I / pharmacology*
  • Nerve Regeneration / drug effects*
  • Neurons, Afferent / drug effects
  • Neurons, Afferent / physiology
  • Rats
  • Rats, Inbred Strains
  • Sciatic Nerve / drug effects
  • Sciatic Nerve / physiology*
  • Somatomedins / pharmacology*


  • Immune Sera
  • Somatomedins
  • Insulin-Like Growth Factor I