New frontiers in time-domain diffuse optics, a review

J Biomed Opt. 2016 Sep;21(9):091310. doi: 10.1117/1.JBO.21.9.091310.

Abstract

The recent developments in time-domain diffuse optics that rely on physical concepts (e.g., time-gating and null distance) and advanced photonic components (e.g., vertical cavity source-emitting laser as light sources, single photon avalanche diode, and silicon photomultipliers as detectors, fast-gating circuits, and time-to-digital converters for acquisition) are focused. This study shows how these tools could lead on one hand to compact and wearable time-domain devices for point-of-care diagnostics down to the consumer level and on the other hand to powerful systems with exceptional depth penetration and sensitivity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Absorption, Physicochemical
  • Diffusion
  • Humans
  • Optical Imaging*
  • Scattering, Radiation
  • Time Factors