H3K9me3-mediated repression of KLF6: Discovering a novel tumor suppressor in liposarcoma using a systematic epigenomic approach

Mol Cell Oncol. 2015 Oct 29;3(3):e1093691. doi: 10.1080/23723556.2015.1093691. eCollection 2016 May.


The pathogenesis of well-differentiated and dedifferentiated liposarcoma is poorly understood. We recently reported Kruppel-like factor 6 (KLF6) as a histone H3 lysine 9 trimethyl (H3K9me3)-regulated and differentially expressed transcription factor serving a previously unappreciated tumor suppressor role in liposarcoma. Mechanistically, KLF6 may drive adipocytic differentiation through increased expression of known regulators of adipogenesis.

Keywords: Dedifferentiated; H3K9me3; KLF6; epigenetics; liposarcoma; well differentiated.