Evaluation of efficacy of aloe vera in the treatment of oral submucous fibrosis - a clinical study

J Oral Pathol Med. 2017 Jan;46(1):50-55. doi: 10.1111/jop.12463. Epub 2016 Jun 17.


Background: Oral submucous fibrosis is a chronic disease, treatment of which has largely been symptomatic. Aloe vera has immunomodulatory, anti-inflammatory, wound healing, antioxidant, and antineoplastic activities. All such properties of aloe vera suggest the possibility of its use in the management of oral submucous fibrosis.

Methods: Seventy-four patients of oral submucous fibrosis were randomly divided into 2 groups. Group A patients were treated with systemic (juice) and topical aloe vera (gel) for 3 months. Group B patients were treated with intralesional injection of hydrocortisone and hyaluronidase for 6 weeks with antioxidant supplements for 3 months. Patients were assessed for reduction in burning sensation and increase in mouth opening, cheek flexibility, and tongue protrusion at an interval of 1, 2, and 3 months.

Results: Both the groups showed statistically significant improvements in all the study parameters at the end of study period (P < 0.001). The clinical response to aloe vera was comparable to that of intralesional injections of hydrocortisone and hyaluronidase with antioxidant supplementation.

Conclusion: The study concludes that aloe vera can be an alternative, safe, and effective treatment regime in the management of oral submucous fibrosis. Long-term follow-up studies with larger sample size are recommended.

Keywords: OSMF; aloe vera; hyaluronidase; hydrocortisone.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Administration, Topical
  • Adult
  • Aloe*
  • Anti-Inflammatory Agents / therapeutic use*
  • Drug Therapy, Combination
  • Female
  • Gels
  • Humans
  • Hyaluronoglucosaminidase / therapeutic use
  • Hydrocortisone / therapeutic use*
  • Injections, Intralesional
  • Male
  • Oral Submucous Fibrosis / drug therapy*
  • Oral Submucous Fibrosis / physiopathology
  • Phytotherapy*
  • Plant Extracts / therapeutic use


  • Anti-Inflammatory Agents
  • Gels
  • Plant Extracts
  • Hyaluronoglucosaminidase
  • Hydrocortisone