Stem Cells: A Renaissance in Human Biology Research

Cell. 2016 Jun 16;165(7):1572-1585. doi: 10.1016/j.cell.2016.05.043.


The understanding of human biology and how it relates to that of other species represents an ancient quest. Limited access to human material, particularly during early development, has restricted researchers to only scratching the surface of this inherently challenging subject. Recent technological innovations, such as single cell "omics" and human stem cell derivation, have now greatly accelerated our ability to gain insights into uniquely human biology. The opportunities afforded to delve molecularly into scarce material and to model human embryogenesis and pathophysiological processes are leading to new insights of human development and are changing our understanding of disease and choice of therapy options.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytological Techniques*
  • Embryo Implantation
  • Embryo, Mammalian / metabolism
  • Embryonic Development*
  • Humans
  • Pluripotent Stem Cells / metabolism
  • Stem Cell Research*