SnapShot: Mechanosensing Matrix

Cell. 2016 Jun 16;165(7):1820-1820.e1. doi: 10.1016/j.cell.2016.06.002.


Cells sense and respond to properties of their microenvironment that can affect cell morphology, protein levels and localization, gene expression, and even nuclear integrity. Tissue micro-stiffness, largely influenced by extracellular matrix, varies dramatically within an organism and can be a useful parameter to both clarify and organize a wide range of cell and molecular processes, such as genomic changes in cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomechanical Phenomena*
  • Cell Culture Techniques*
  • Cell Shape
  • Extracellular Matrix / metabolism*
  • Humans
  • Neoplasms / pathology