Magnetic resonance signal abnormalities in asymptomatic individuals: their incidence and functional correlates

Eur Neurol. 1989;29(3):164-8. doi: 10.1159/000116401.


MR signal abnormalities were assessed in 87 symptom-free volunteers (31-83 years of age) and correlated with cerebrovascular risk factors, cerebral blood flow and glucose metabolism. Lesions in the subcortical and deep white matter increased from 11% in the 4th decade to 83% in subjects over 70 years of age, and were detected significantly more often in individuals with cerebrovascular risk factors (p less than 0.01). They were associated with lower slow-compartmental flow (p less than 0.05) but did not affect adjacent cortical glucose metabolism. Periventricular signal changes also increased with age but were unrelated to risk factors or functional data.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Brain / metabolism
  • Brain Diseases / diagnosis*
  • Cerebral Ventricles* / pathology
  • Cerebrovascular Circulation
  • Female
  • Glucose / metabolism
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Regional Blood Flow


  • Glucose