Analysis of circulatory mitochondrial DNA level after cardiac surgery with cardiopulmonary bypass and potential prognostic implications

Chaoyi Qin; Jun Gu; Hong Qian; Wei Meng

doi:10.1016/j.ihj.2016.04.014

Analysis of circulatory mitochondrial DNA level after cardiac surgery with cardiopulmonary bypass and potential prognostic implications

Indian Heart J. 2016 May-Jun;68(3):389-90. doi: 10.1016/j.ihj.2016.04.014. Epub 2016 May 7.

Authors

Chaoyi Qin¹, Jun Gu¹, Hong Qian¹, Wei Meng²

Affiliations

¹ Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China.
² Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China. Electronic address: meng_wei_1111@yahoo.com.

Abstract

Our research letter found that circulatory mtDNA level increased after the end of CPB and positive correlations between mtDNA and peak CRP level, peak BNP level, and peak PCT level, which revealed the prognostic role of perioperative circulatory mtDNA level in patients who underwent cardiopulmonary bypass.

Keywords: Cardiopulmonary bypass; Mitochondrial DNA; Prognostic predictor.

Publication types

Letter

MeSH terms

Biomarkers / blood
C-Reactive Protein / metabolism*
Cardiac Surgical Procedures / methods*
Cardiopulmonary Bypass*
DNA, Mitochondrial / blood*
Female
Follow-Up Studies
Heart Valve Diseases / blood
Heart Valve Diseases / surgery
Humans
Male
Middle Aged
Postoperative Complications / blood*
Postoperative Period
Prognosis
Retrospective Studies

Substances

Biomarkers
DNA, Mitochondrial
C-Reactive Protein