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, 11 (5), 607-9

Quantitative Determination of Vinpocetine in Dietary Supplements

Quantitative Determination of Vinpocetine in Dietary Supplements

John M T French et al. Nat Prod Commun.

Abstract

Current United States regulatory policies allow for the addition of pharmacologically active substances in dietary supplements if derived from a botanical source. The inclusion of certain nootropic drugs, such as vinpocetine, in dietary supplements has recently come under scrutiny due to the lack of defined dosage parameters and yet unproven short- and long-term benefits and risks to human health. This study quantified the concentration of vinpocetine in several commercially available dietary supplements and found that a highly variable range of 0.6-5.1 mg/serving was present across the tested products, with most products providing no specification of vinpocetine concentrations.

Figures

Figure 1
Figure 1
Chemical structures of vincamine (left) and the semi-synthetic derivative vinpocetine (right).
Figure 2
Figure 2
HPLC-UV chromatogram obtained for product B. Retention times for vinpocetine and DL-propranolol are at 11.9 and 9.9 minutes, respectively.

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