Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Aug;57(8):e173-7.
doi: 10.1111/epi.13437. Epub 2016 Jun 20.

Withdrawal of Valproic Acid Treatment During Pregnancy and Seizure Outcome: Observations From EURAP

Affiliations
Free article

Withdrawal of Valproic Acid Treatment During Pregnancy and Seizure Outcome: Observations From EURAP

Torbjörn Tomson et al. Epilepsia. .
Free article

Abstract

Based on data from the EURAP observational International registry of antiepileptic drugs (AEDs) and pregnancy, we assessed changes in seizure control and subsequent AED changes in women who underwent attempts to withdraw valproic acid (VPA) during the first trimester of pregnancy. Applying Bayesian statistics, we compared seizure control in pregnancies where VPA was withdrawn (withdrawal group, n = 93), switched to another AED (switch group, n = 38), or maintained (maintained-therapy group, n = 1,588) during the first trimester. The probability of primarily or secondarily generalized tonic-clonic seizures (GTCS) was lower in the maintained-therapy group compared with the other two groups, both in the first trimester and for the entire duration of pregnancy. GTCS were twice as common during pregnancy in the withdrawal (33%) and switch groups (29%) compared with the maintained-treatment group (16%). Limitations in the data and study design do not allow to establish a cause-effect relationship between treatment changes and seizure outcome, but these observations provide a signal that withdrawal of, or switch from, VPA during the first trimester could lead to loss of seizure control, and highlight the need for a specifically designed prospective observational study.

Keywords: Epilepsy; Pregnancy; Seizures; Valproic acid.

Similar articles

See all similar articles

Cited by 6 articles

See all "Cited by" articles

Publication types

Feedback