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. 1978 Feb;75(2):559-63.
doi: 10.1073/pnas.75.2.559.

Respective Roles of Short- And Long-Range Interactions in Protein Folding

Free PMC article

Respective Roles of Short- And Long-Range Interactions in Protein Folding

N Go et al. Proc Natl Acad Sci U S A. .
Free PMC article

Abstract

A lattice model of protein is studied by a Monte Carlo simulation method. The native conformation of the lattice protein molecule is stabilized by specific long-range and short-ranged interactions. By comparing results of simulation for different relative weights of the long- and short-range interactions, it is concluded that the specific long-range interactions are essential for highly cooperative stabilization of the native conformation and that the short-range interactions accelerate the folding and unfolding transitions.

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