Controllable Self-Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting

Adv Mater. 2016 Sep;28(34):7501-7. doi: 10.1002/adma.201601976. Epub 2016 Jun 20.


RNA tetrahedral nanoparticles with two different sizes are successfully assembled by a one-pot bottom-up approach with high efficiency and thermal stability. The reported design principles can be extended to construct higher-order polyhedral RNA architectures for various applications such as targeted cancer imaging and therapy.

Keywords: Phi29 packaging RNA; RNA nanoparticles; RNA nanotechnology; tetrahedrons; three-way junctions.

MeSH terms

  • Nanoparticles
  • Nanotechnology
  • RNA / chemistry*


  • RNA