The Potential for Microalgae as Bioreactors to Produce Pharmaceuticals

doi:10.3390/ijms17060962

Review

. 2016 Jun 17;17(6):962.

doi: 10.3390/ijms17060962.

The Potential for Microalgae as Bioreactors to Produce Pharmaceuticals

Na Yan^{1

2}, Chengming Fan³, Yuhong Chen⁴, Zanmin Hu⁵

Affiliations

¹ Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. yanna19881204@163.com.
² University of Chinese Academy of Sciences, Beijing 100049, China. yanna19881204@163.com.
³ Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. cmfan@genetics.ac.cn.
⁴ Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. yhchen@genetics.ac.cn.
⁵ Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. zmhu@genetics.ac.cn.

PMID: 27322258
PMCID: PMC4926494
DOI: 10.3390/ijms17060962

Review

The Potential for Microalgae as Bioreactors to Produce Pharmaceuticals

Na Yan et al. Int J Mol Sci. 2016.

. 2016 Jun 17;17(6):962.

doi: 10.3390/ijms17060962.

Authors

Na Yan^{1

2}, Chengming Fan³, Yuhong Chen⁴, Zanmin Hu⁵

Affiliations

¹ Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. yanna19881204@163.com.
² University of Chinese Academy of Sciences, Beijing 100049, China. yanna19881204@163.com.
³ Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. cmfan@genetics.ac.cn.
⁴ Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. yhchen@genetics.ac.cn.
⁵ Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. zmhu@genetics.ac.cn.

PMID: 27322258
PMCID: PMC4926494
DOI: 10.3390/ijms17060962

Abstract

As photosynthetic organisms, microalgae can efficiently convert solar energy into biomass. Microalgae are currently used as an important source of valuable natural biologically active molecules, such as carotenoids, chlorophyll, long-chain polyunsaturated fatty acids, phycobiliproteins, carotenoids and enzymes. Significant advances have been achieved in microalgae biotechnology over the last decade, and the use of microalgae as bioreactors for expressing recombinant proteins is receiving increased interest. Compared with the bioreactor systems that are currently in use, microalgae may be an attractive alternative for the production of pharmaceuticals, recombinant proteins and other valuable products. Products synthesized via the genetic engineering of microalgae include vaccines, antibodies, enzymes, blood-clotting factors, immune regulators, growth factors, hormones, and other valuable products, such as the anticancer agent Taxol. In this paper, we briefly compare the currently used bioreactor systems, summarize the progress in genetic engineering of microalgae, and discuss the potential for microalgae as bioreactors to produce pharmaceuticals.

Keywords: bioreactor; microalgae; pharmaceuticals; recombinant proteins.

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References

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[1] Demain A.L., Vaishnav P. Production of recombinant proteins by microbes and higher organisms. Biotechnol. Adv. 2009;27:297–306. doi: 10.1016/j.biotechadv.2009.01.008. - DOI - PubMed

[2] Demain A.L., Vaishnav P. Production of recombinant proteins by microbes and higher organisms. Biotechnol. Adv. 2009;27:297–306. doi: 10.1016/j.biotechadv.2009.01.008. - DOI - PubMed

[3] Ferrer-Miralles N., Domingo-Espín J., Corchero J.L., Vázquez E., Villaverde A. Microbial factories for recombinant pharmaceuticals. Microb. Cell Fact. 2009;8:17. doi: 10.1186/1475-2859-8-17. - DOI - PMC - PubMed

[4] Ferrer-Miralles N., Domingo-Espín J., Corchero J.L., Vázquez E., Villaverde A. Microbial factories for recombinant pharmaceuticals. Microb. Cell Fact. 2009;8:17. doi: 10.1186/1475-2859-8-17. - DOI - PMC - PubMed

[5] Corchero J.L., Gasser B., Resina D., Smith W., Parrilli E., Vázquez F., Abasolo I., Giuliani M., Jäntti J., Ferrer P. Unconventional microbial systems for the cost-efficient production of high-quality protein therapeutics. Biotechnol. Adv. 2013;31:140–153. doi: 10.1016/j.biotechadv.2012.09.001. - DOI - PubMed

[6] Corchero J.L., Gasser B., Resina D., Smith W., Parrilli E., Vázquez F., Abasolo I., Giuliani M., Jäntti J., Ferrer P. Unconventional microbial systems for the cost-efficient production of high-quality protein therapeutics. Biotechnol. Adv. 2013;31:140–153. doi: 10.1016/j.biotechadv.2012.09.001. - DOI - PubMed

[7] Sanchez S., Demain A.L. Enzymes and bioconversions of industrial, pharmaceutical, and biotechnological significance. Org. Process Res. Dev. 2010;15:224–230. doi: 10.1021/op100302x. - DOI

[8] Sanchez S., Demain A.L. Enzymes and bioconversions of industrial, pharmaceutical, and biotechnological significance. Org. Process Res. Dev. 2010;15:224–230. doi: 10.1021/op100302x. - DOI

[9] Cereghino G.P.L., Cregg J.M. Applications of yeast in biotechnology: Protein production and genetic analysis. Curr. Opin. Biotechnol. 1999;10:422–427. doi: 10.1016/S0958-1669(99)00004-X. - DOI - PubMed

[10] Cereghino G.P.L., Cregg J.M. Applications of yeast in biotechnology: Protein production and genetic analysis. Curr. Opin. Biotechnol. 1999;10:422–427. doi: 10.1016/S0958-1669(99)00004-X. - DOI - PubMed

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The Potential for Microalgae as Bioreactors to Produce Pharmaceuticals

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The Potential for Microalgae as Bioreactors to Produce Pharmaceuticals

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