Protective Effect of Morocco Carob Honey Against Lead-Induced Anemia and Hepato-Renal Toxicity

Cell Physiol Biochem. 2016;39(1):115-22. doi: 10.1159/000445610. Epub 2016 Jun 20.


Background/aims: Natural honey has many biological activities including protective effect against toxic materials. The aim of this study was to evaluate the protective effect of carob honey against lead-induced hepato-renal toxicity and lead-induced anemia in rabbits.

Methods: Twenty four male rabbits were allocated into four groups six rabbits each; group 1: control group, received distilled water (0.1 ml / kg.b.wt /daily); group 2: received oral lead acetate (2 g/kg.b.wt/daily); group 3: treated with oral honey (1g /kg.b.wt/daily) and oral lead (2 g/kg.b.wt/daily), and group 4: received oral honey (1 g/kg.b.wt/daily). Honey and lead were given daily during 24 days of experimentation. Laboratory tests and histopathological evaluations of kidneys were done.

Results: Oral administration of lead induced hepatic and kidney injury and caused anemia during three weeks of the exposure. Treatment with honey prevented hepato-renal lead toxicity and ameliorated lead-induced anemia when honey was given to animals during lead exposure.

Conclusion: It might be concluded that honey has a protective effect against lead-induced blood, hepatic and renal toxic effects.

MeSH terms

  • Administration, Oral
  • Anemia / chemically induced
  • Anemia / prevention & control*
  • Animals
  • Body Weight / drug effects
  • Creatinine / blood
  • Hemoglobins / metabolism
  • Honey*
  • Kidney / drug effects*
  • Kidney / pathology
  • Kidney / physiopathology
  • Lead / administration & dosage
  • Lead / toxicity*
  • Leukocyte Count
  • Liver / drug effects*
  • Liver / pathology
  • Liver / physiopathology
  • Male
  • Morocco
  • Protective Agents / administration & dosage
  • Protective Agents / pharmacology*
  • Rabbits
  • Time Factors


  • Hemoglobins
  • Protective Agents
  • Lead
  • Creatinine