Efficacy of topical chamomile management vs. placebo in patients with oral lichen planus: a randomized double-blind study

J Eur Acad Dermatol Venereol. 2016 Oct;30(10):1783-1786. doi: 10.1111/jdv.13770. Epub 2016 Jun 21.


Background: The purpose of this study was to compare the clinical therapeutic efficacy of topical applications of chamomile vs. a placebo for treating oral lichen planus (OLP).

Methods: This double-blind study, randomly divided 60 patients with OLP into two groups, 30 treated with 2% Chamaemelum nobile gel (0.5 mL/3 times a day) and 30 treated with a placebo (Trial Registration NCT02421770). A visual analogue scale was used to rate pain, itching and burning sensation, and Thongprasom Index, the Oral Health Impact Profile 14 (OHIP-14) and the Hospital Anxiety-Depression Scale. Patients were evaluated at baseline and after 4 weeks of treatment.

Results: Patients treated with chamomile showed significant improvements after 4 weeks for pain (P < 0.001), burning sensation (P < 0.001), itching (P = 0.011), OHIP-14 (P < 0.001) and Thongprasom index (P = 0.001); 92% of patients treated with chamomile showed a partial or total response, while only five subjects (17%) in the placebo group showed any improvement.

Conclusion: The topical application of 2% chamomile gel is an effective treatment for OLP.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Aged
  • Chamomile*
  • Double-Blind Method
  • Female
  • Humans
  • Lichen Planus, Oral / therapy*
  • Male
  • Middle Aged
  • Placebos


  • Placebos