Systematic review of green tea epigallocatechin gallate in reducing low-density lipoprotein cholesterol levels of humans

Int J Food Sci Nutr. 2016 Sep;67(6):606-13. doi: 10.1080/09637486.2016.1196655. Epub 2016 Jun 20.


We conducted a systematic review of the literature for the ability of green tea epigallocatechin gallate (EGCG) to lower low-density lipoprotein cholesterol (LDL-C). Study subjects were limited to healthy individuals and randomized, controlled trials on human serum lipid levels, especially LDL-C, conducted. A total of 17 trials (n = 1356) met all of the inclusion criteria. According to weighted mean differences for changes from baseline with 95% confidence intervals (CI), 107-856 mg/d of EGCG for 4 to 14 weeks reduced LDL-C by -9.29 mg/dl (95% CI, -12.27 to -6.31). Sub-analysis was performed to compare the EGCG lowering effect on LDL-C between non-obese and obese subjects, EGCG dose, baseline of LDL-C levels, or BMI. We concluded that consumption of green tea EGCG resulted in a significant reduction of LDL-C at any baseline level and any dose between 107 and 856 mg/d, and the effect size was slightly dependent on the baseline lipid level of the subjects.

Keywords: Catechin; flavonoid; lipid profile; polyphenol.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Body Mass Index
  • Catechin / analogs & derivatives*
  • Catechin / pharmacology
  • Cholesterol, LDL / blood*
  • Humans
  • Obesity / blood
  • Plant Extracts / pharmacology
  • Randomized Controlled Trials as Topic
  • Tea / chemistry*


  • Cholesterol, LDL
  • Plant Extracts
  • Tea
  • Catechin
  • epigallocatechin gallate