Effects of topical application of B-Resorcinol and Glycyrrhetinic acid monotherapy and in combination with fractional CO 2 laser treatment for benign hand hyperpigmentation treatment

J Cosmet Dermatol. 2016 Dec;15(4):413-419. doi: 10.1111/jocd.12241. Epub 2016 Jun 21.


Background: Hand solar lentigines are frequent benign lesions of elderly population, requiring longtime treatments with topical agents or laser to lighten.

Aims: The aim of this study was to evaluate and compare the efficacy of CO2 fractional laser photothermolysis followed by topical application of B-Resorcinol and Glycyrrhetinic acid vs. only topical B-Resorcinol and Glycyrrhetinic acid application for hand solar lentigines treatment.

Methods: Hand solar lentigines of eleven volunteers were divided into two groups: Group A spots received CO2 fractional laser photothermolysis followed by 4 weeks topical application of B-Resorcinol and Glycyrrhetinic acid, and Group B spots received only 4 weeks topical treatments. All hands were photographed, and hand solar lentigines scanned with dermatoscope at the beginning of the study (T0 ), 1 month after laser treatment (T1 ), and at the end of the study (T2 ) to document spots dimensions and color. A blinded dermatologist evaluated dermoscopic T0 and T2 images. The considered variables were assessed for significance by the nonparametric Mann-Whitney U-test.

Results: In all volunteers, investigators and blinded dermatologist's evaluation hand solar lentigines features improved, with no statistical differences in the two groups.

Conclusion: Topical application of B-Resorcinol and Glycyrrhetinic acid is effective to lighten hand solar lentigines after 4 weeks of treatment, with or without a previous fractional laser photothermolysis.

Keywords: dermatoscope; lasers and light sources; solar lentigines; topical agents.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Cutaneous
  • Adult
  • Aged
  • Anti-Inflammatory Agents / administration & dosage*
  • Combined Modality Therapy
  • Dermoscopy
  • Female
  • Glycyrrhetinic Acid / administration & dosage*
  • Hand Dermatoses / therapy*
  • Humans
  • Lasers, Gas / therapeutic use*
  • Lentigo / diagnostic imaging
  • Lentigo / therapy*
  • Male
  • Middle Aged
  • Photography
  • Prospective Studies
  • Resorcinols / administration & dosage*
  • Single-Blind Method


  • 4-n-butylresorcinol
  • Anti-Inflammatory Agents
  • Resorcinols
  • Glycyrrhetinic Acid