Synthesis of Natural Cyclopentapeptides Isolated from Dianthus chinensis

J Nat Prod. 2016 Jul 22;79(7):1769-74. doi: 10.1021/acs.jnatprod.6b00152. Epub 2016 Jun 21.


The first syntheses of the naturally occurring cyclic peptides dianthin I (1), pseudostellarin A (2), and heterophyllin J (3) are described. The linear protected peptide precursors were prepared efficiently via Fmoc-solid-phase synthesis and subsequently cyclized in solution under dilute conditions. The structures of the synthetic cyclopentapeptides were confirmed by NMR spectroscopy and mass spectrometry and were in agreement with the literature data reported for the natural products.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dianthus / chemistry*
  • Molecular Structure
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification*
  • Solid-Phase Synthesis Techniques


  • Peptides, Cyclic
  • dianthin I
  • heterophyllin J
  • pseudostellarin A