Abstract
Hybridization of RNA to its template DNA strand during transcription induces formation of R-loops-RNA:DNA hybrids with unpaired non-template DNA strands. Although unresolved R-loops can be detrimental, some R-loops contribute to regulation of chromatin structure. Consequently, R-loops help regulate gene expression and play important roles in numerous cellular processes.
Keywords:
R-loops; chromatin; embryonic stem cells; nucleosome; pluripotency.
Publication types
-
Review
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Base Pairing
-
Chromatin / genetics*
-
Chromatin Assembly and Disassembly*
-
DNA / chemistry
-
DNA / genetics*
-
DNA Methylation
-
DNA-Binding Proteins / genetics
-
DNA-Binding Proteins / metabolism
-
Embryonic Stem Cells / cytology
-
Embryonic Stem Cells / metabolism
-
Histones / metabolism
-
Humans
-
Methylation
-
Mutation
-
Protein Binding
-
RNA / chemistry
-
RNA / genetics*
Substances
-
Chromatin
-
DNA-Binding Proteins
-
Histones
-
RNA
-
DNA