Comparison of a supplemented Rose Questionnaire to exercise thallium testing in men and women

J Clin Epidemiol. 1989;42(5):385-94. doi: 10.1016/0895-4356(89)90126-1.


The Rose Questionnaire has had high specificity and variable sensitivity when compared to physician identification of the symptom complex of angina pectoris. We assessed the accuracy of a supplemented Rose Questionnaire in a series of 198 patients by comparing the Questionnaire to exercise thallium test evidence of coronary artery disease. The Rose diagnosis of angina had 26% sensitivity, 79% specificity, 42% positive predictive value, and 65% negative predictive value. The Rose diagnosis of myocardial infarction had 26% sensitivity and 90% specificity. The Rose diagnosis of angina or infarction yielded a sensitivity of 44%, specificity of 72%, positive predictive value of 67%, and negative predictive value of 50%. Supplemental questions designed to identify atypical ischemic pain led to increased sensitivity of up to 68% that was offset by decreased specificity. While the Questionnaire's sensitivity for coronary disease was greater for women than men (57 vs 40%), the overall accuracy was the same because specificity was lower (63 vs 80%).

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Angina Pectoris / diagnosis*
  • Angina Pectoris / epidemiology
  • Exercise Test
  • Female
  • Humans
  • Male
  • Middle Aged
  • Sex Factors
  • Surveys and Questionnaires
  • Thallium Radioisotopes*


  • Thallium Radioisotopes