Adult brainstem gliomas

Cancer. 2016 Sep 15;122(18):2799-809. doi: 10.1002/cncr.29920. Epub 2016 Jun 21.


Brainstem gliomas in adults are a rare and heterogeneous group of brain tumors that vary with regard to underlying pathology, radiographic appearance, clinical course and prognosis. Diffuse intrinsic pontine gliomas represent the most common subtype. Although still considered aggressive and most often lethal, these brain tumors are associated with a more insidious clinical course and more favorable prognosis compared to the highly aggressive form in children. Treatment options for patients with brainstem gliomas still are limited and insufficiently studied. A better understanding of the pathobiology of these tumors will be crucial for the development of more specific and effective therapies. Cancer 2016. © 2016 American Cancer Society. Cancer 2016;122:2799-2809. © 2016 American Cancer Society.

Keywords: adults; brainstem gliomas; diffuse intrinsic pontine gliomas; magnetic resonance spectroscopy; pathology.

Publication types

  • Review

MeSH terms

  • Adult
  • Brain Stem Neoplasms / pathology*
  • Brain Stem Neoplasms / therapy
  • Glioma / pathology*
  • Glioma / therapy
  • Humans
  • Prognosis