The evolution of innate lymphoid cells

Nat Immunol. 2016 Jun 21;17(7):790-4. doi: 10.1038/ni.3459.


Innate lymphoid cells (ILCs) are the most recently discovered group of immune cells. Understanding their biology poses many challenges. We discuss here the current knowledge on the appearance of ILC subsets during evolution and propose how the connection between ILCs and T cells contributes to the robustness of immunity and hence to the fitness of the hosts.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Biological Evolution*
  • Cell Differentiation
  • Host-Pathogen Interactions
  • Humans
  • Immunity, Innate*
  • Lymphocyte Subsets / immunology*
  • Lymphocytes / immunology*
  • T-Lymphocytes / immunology*