John Ioannidis argues that problem base, context placement, information gain, pragmatism, patient centeredness, value for money, feasibility, and transparency define useful clinical research. He suggests most clinical research is not useful and reform is overdue.
Research Support, Non-U.S. Gov't
Biomedical Research / classification
Biomedical Research / organization & administration
Biomedical Research / standards*
The Meta-Research Innovation Center at Stanford (METRICS) is funded by a grant from the Laura and John Arnold Foundation (http://www.arnoldfoundation.org
). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.