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. 2017 Feb;19(2):194-200.
doi: 10.1080/10286020.2016.1196671. Epub 2016 Jun 22.

Cytototoxic Constituents From the Bark of Chisocheton Cumingianus (Meliaceae)

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Cytototoxic Constituents From the Bark of Chisocheton Cumingianus (Meliaceae)

Dewa Gede Katja et al. J Asian Nat Prod Res. .

Abstract

A new lanostane-type triterpenoid, 3β-hydroxy-25-ethyl-lanost-9(11),24(24')-diene (1), along with 3β-hydroxy-lanost-7-ene (2) and β-sitosterol-3-O-acetate (3) was isolated from the stem bark of C. cumingianus. The chemical structure of the new compound was elucidated on the basis of spectroscopic data. All of the compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1-3 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 28.8 ± 0.10, 4.29 ± 0.03, and 100.18 ± 0.16 μg/ml, respectively.

Keywords: Chisocheton cumingianus; Lanostane-type triterpenoid; Meliaceae; cytotoxic activity.

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