First-Line Atezolizumab Effective in Bladder Cancer

Cancer Discov. 2016 Aug;6(8):OF7. doi: 10.1158/2159-8290.CD-NB2016-076. Epub 2016 Jun 21.

Abstract

Results from a phase II study indicate that the PD-L1 inhibitor atezolizumab, recently approved for advanced bladder cancer that's refractory to standard platinum chemotherapy, is effective as first-line therapy for this disease. Durable responses to atezolizumab were seen in nearly a quarter of the study patients, who were all ineligible to receive cisplatin.

Publication types

  • Congress

MeSH terms

  • Antibodies, Monoclonal / therapeutic use*
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents / therapeutic use*
  • Clinical Trials, Phase III as Topic
  • Humans
  • Survival Analysis
  • Treatment Outcome
  • Urinary Bladder Neoplasms / drug therapy*

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents
  • atezolizumab