Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 5, 637
eCollection

Recent Advances in Migraine Therapy

Affiliations
Review

Recent Advances in Migraine Therapy

Fabio Antonaci et al. Springerplus.

Abstract

Migraine is a common and highly disabling neurological disorder associated with a high socioeconomic burden. Effective migraine management depends on adequate patient education: to avoid unrealistic expectations, the condition must be carefully explained to the patient soon as it is diagnosed. The range of available acute treatments has increased over time. At present, abortive migraine therapy can be classed as specific (ergot derivatives and triptans) or non-specific (analgesics and non-steroidal anti-inflammatory drugs). Even though acute symptomatic therapy can be optimised, migraine continues to be a chronic and potentially progressive condition. In addition to the drugs officially approved for migraine prevention by international governmental regulatory agencies, numerous different agents are commonly used for this indication, showing various levels of evidence of efficacy and tolerability. Guidelines published in recent years, based on evidence-based medicine data on migraine prophylaxis, are a useful source of guidance, especially for primary care physicians and neurologists without specific expertise in headache medicine. Although the field of pharmacological migraine prevention has seen few advances in recent years, potential novel approaches are now being developed. This review looks at emerging pharmacological strategies for acute and preventive migraine treatment that are nearing or have already entered the clinical trial phase. Specifically, it discusses preclinical and clinical data on compounds acting on calcitonin gene-related peptide or its receptor, the serotonin 5-HT1F receptor, nitric oxide synthase, and acid-sensing ion channel blockers.

Keywords: Acute treatment; Migraine; Preventive treatment.

Similar articles

See all similar articles

Cited by 16 PubMed Central articles

See all "Cited by" articles

References

    1. Ambrosini A, C D’Alessio C, Magis D, Schoenen J (2015) Targeting pericranial nerve branches to treat migraine: current approaches and perspectives. Cephalalgia. pii: 0333102415573511. (Epub ahead of print) - PubMed
    1. Andreou AP, Goadsby PJ. Therapeutic potential of novel glutamate receptor antagonists in migraine. Expert Opin Investig Drugs. 2009;18(6):789–803. doi: 10.1517/13543780902913792. - DOI - PubMed
    1. Antonaci F, De Cillis I, Cuzzoni MG, Allena M. Almotriptan for the treatment of acute migraine: a review of early intervention trials. Expert Rev Neurother. 2010;10(3):351–364. doi: 10.1586/ern.09.160. - DOI - PubMed
    1. Antonaci F, Ghiotto N, Evangelista M. An overview of the treatment options for acute migraine. Eur Neurol Rev. 2011;6(4):273–277. doi: 10.17925/ENR.2011.06.04.265. - DOI
    1. Arcioni R, Palmisani S, Mercieri M, Vano V, Tigano S, Smith T, Fiore MR, Al-Kaisy A, Martelletti P. Cervical 10 kHz spinal cord stimulation in the management of chronic, medically refractory migraine: a prospective, open-label, exploratory study. Eur J Pain. 2016;20(1):70–78. doi: 10.1002/ejp.692. - DOI - PubMed

LinkOut - more resources

Feedback