This study is to develop a nursing information system (NIS) training program, and takes a local community teaching hospital in Taiwan for example. We adopt the ADDIE model to develop our NIS training program. We preliminaries followed the framework of the model to design a NIS training program, and implement it for the newcomers' training of nursing information system. After training course, the self-efficacy report has a significant (p<.000) improved compare to pre-test, and 88% of participants passed the pragmatic exam.