Taurine Ameliorates Renal Oxidative Damage and Thyroid Dysfunction in Rats Chronically Exposed to Fluoride

Biol Trace Elem Res. 2017 Feb;175(2):388-395. doi: 10.1007/s12011-016-0784-2. Epub 2016 Jun 22.

Abstract

Excessive exposure to fluoride poses several detrimental effects to human health particularly the kidney which is a major organ involved in its elimination from the body. The influence of taurine on fluoride-induced renal toxicity was investigated in a co-exposure paradigm for 45 days using five groups of eight rats each. Group I rats received normal drinking water alone, group II rats were exposed to sodium fluoride (NaF) in drinking water at 15 mg/L alone, group III received taurine alone at a dose of 200 mg/kg group IV rats were co-administered with NaF and taurine (100 mg/kg), while group V rats were co-administered with NaF and taurine (200 mg/kg). Administration of taurine significantly reversed the fluoride-mediated decrease in absolute weight and organo-somatic index of the kidney in the exposed rats. Taurine significantly prevented fluoride-induced elevation in plasma urea and creatinine levels in the exposed rats. Moreover, taurine restored fluoride-mediated decrease in the circulatory concentrations of triiodothyronine, thyroxine, and the ratio of triiodothyronine to thyroxine. Taurine ameliorated fluoride-mediated decrease in renal antioxidant status by significantly enhancing the antioxidant enzyme activities as well as glutathione level in the exposed rats. Additionally, taurine inhibited fluoride-induced renal oxidative damage by markedly decreasing the hydrogen peroxide and malondialdehyde levels as well as improved the kidney architecture in the treated rats. Collectively, taurine protected against fluoride-induced renal toxicity via enhancement of thyroid gland function, renal antioxidant status, and histology in rats.

Keywords: Fluoride; Rats; Renal toxicity; Taurine; Thyroid hormones.

MeSH terms

  • Animals
  • Fluorides / toxicity*
  • Kidney / metabolism*
  • Kidney / pathology
  • Kidney Diseases* / chemically induced
  • Kidney Diseases* / metabolism
  • Kidney Diseases* / pathology
  • Kidney Diseases* / prevention & control
  • Male
  • Oxidative Stress / drug effects*
  • Rats
  • Rats, Wistar
  • Taurine / pharmacology*
  • Thyroid Diseases* / chemically induced
  • Thyroid Diseases* / metabolism
  • Thyroid Diseases* / pathology
  • Thyroid Diseases* / prevention & control
  • Thyroid Gland / metabolism*
  • Thyroid Gland / pathology

Substances

  • Taurine
  • Fluorides