Wnt/β-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration

FASEB J. 2016 Oct;30(10):3271-3284. doi: 10.1096/fj.201600502R. Epub 2016 Jun 22.

Abstract

The Wnt/β-catenin pathway is an evolutionarily conserved set of signals with critical roles in embryonic and neonatal development across species. In mammals the pathway is quiescent in many organs. It is reactivated in response to injury and is reported to play complex and contrasting roles in promoting regeneration and fibrosis. We review the current understanding of the role of the Wnt/β-catenin pathway in injury of various mammalian organs and discuss the current advances and potential of Wnt inhibitory therapeutics toward promoting tissue regeneration and reducing fibrosis.-Bastakoty, D., Young, P. P. Wnt/β-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration.

Keywords: fibrosis; inhibitor; repair; scar; wound healing.

Publication types

  • Review
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Regeneration / physiology*
  • Signal Transduction / physiology*
  • Wnt Proteins / metabolism*
  • Wnt Signaling Pathway / physiology*
  • Wound Healing / physiology*
  • beta Catenin / metabolism*

Substances

  • Wnt Proteins
  • beta Catenin