The Level of Cholesterol in COPD Patients with Severe and Very Severe Stage of the Disease

Beti Zafirova-Ivanovska; Jagoda Stojkovikj; Dejan Dokikj; Sasha Anastasova; Angela Debresliovska; Sead Zejnel; Dragana Stojkovikj

doi:10.3889/oamjms.2016.063

The Level of Cholesterol in COPD Patients with Severe and Very Severe Stage of the Disease

Open Access Maced J Med Sci. 2016 Jun 15;4(2):277-82. doi: 10.3889/oamjms.2016.063. Epub 2016 May 24.

Authors

Beti Zafirova-Ivanovska¹, Jagoda Stojkovikj², Dejan Dokikj², Sasha Anastasova³, Angela Debresliovska², Sead Zejnel², Dragana Stojkovikj⁴

Affiliations

¹ Institute for Epidemiology and Biostatistics and Medical Informatics, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
² University Clinic of Pulmonology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
³ University Clinic of Cardiology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
⁴ School of Doctoral Studies at Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Abstract

Background: High blood cholesterol is part of metabolic syndrome and can be caused by medical conditions or bad dietary habits.

Aim: The aim of the study was to investigate the prevalence of hypercholesterolemia in privies diagnosed patients with the severe and very severe stage of COPD, which were stable.

Material and methods: We investigated 100 subjects, all of them smokers, with smoking status >10 years, stratified into two groups: with severe and very severe stage of the disease. It was clinical, randomized, cross-sectional study. Besides demographic parameters and functional parameters, body mass index, cholesterol, LDL, and HDL were investigated.

Results: In the group of patients with very severe COPD were recorded significantly higher average values of cholesterol (6.16 ± 1.5 vs. 5.61 ± 1.1, p = 0.039). As independent significant factors influencing cholesterol in the group with a very severe COPD were confirmed the age of the patients (p = 0.005), LDL (p = 0.004) and HDL (p = 0.002). In the group with severe COPD, only LDL was confirmed as an independent significant factor that has an impact on cholesterol (p < 0.0001).

Conclusion: The results of our survey demonstrated a high level of blood cholesterol and LDL, and low level of blood HDL in both investigated group's patients with COPD.

Keywords: comorbidity; severe and very severe COPD; the level of HDL; the level of LDL; the level of cholesterol.